Nature Reviews Genetics: RNAi Video
http://www.nature.com/nrg/multimedia/rnai/animation/index.html
http://bcove.me/kr3emoyb
The biology of dsRNAs
- How are dsRNAs produced? Simultaneous sense and antisense transcription?
- Adenosine deaminases acting on RNA (ADAR)
- ADAR editases post-transcriptionally deaminate adenosine to inosine (A to I)
- Editing most common with primate-specific Alu repeats
- ADAR1 germline deletion induces embryonic lethality through impaired embryogenesis
- Conditional ADAR1 deletion induces interferon signalling