Ultraviolet
Ultraviolet (UV) light is electromagnetic radiation with a wavelength shorter than that of visible light but longer than X-rays (from 400 nm to 10 nm in wavelength).
UVB light can cause direct DNA damage.
UVA - 400 – 315 nm
UVB - 315 – 280 nm
UVC - 280 – 100 nm
Absorption of ultraviolet (UV) light produces two predominant types of DNA damage:
i) cyclobutane pyrimidine dimers (CPD)
ii) pyrimidine (6-4) pyrimidone photoproducts (6-4PP)
The result is a transition of C to T and CC to TT, which are the most frequent mutations of p53 in both human and mouse skin cancers.
Ultraviolet (UV) light is electromagnetic radiation with a wavelength shorter than that of visible light but longer than X-rays (from 400 nm to 10 nm in wavelength).
UVB light can cause direct DNA damage.
UVA - 400 – 315 nm
UVB - 315 – 280 nm
UVC - 280 – 100 nm
Absorption of ultraviolet (UV) light produces two predominant types of DNA damage:
i) cyclobutane pyrimidine dimers (CPD)
ii) pyrimidine (6-4) pyrimidone photoproducts (6-4PP)
The result is a transition of C to T and CC to TT, which are the most frequent mutations of p53 in both human and mouse skin cancers.
Response:
UV damaged DNA is usually repaired by nucleotide excision repair (NER) or base excision repair (BER). After UV exposure, cells activate p53 and stall the cell cycle for repair. If the damage is too severe, the cell will trigger apoptosis to get rid of DNA damaged, potentially mutant cells.
UV damaged DNA is usually repaired by nucleotide excision repair (NER) or base excision repair (BER). After UV exposure, cells activate p53 and stall the cell cycle for repair. If the damage is too severe, the cell will trigger apoptosis to get rid of DNA damaged, potentially mutant cells.